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Dr. Sukandar received his Ph.D degree (2020) in organic chemistry from Chulalongkorn University -CU under supervision of Prof. Santi Tip-pyang on bioactive molecules exploration from Indonesian Garcinia species as anticancer candidates. During his doctoral study, he also joined Prof. Rudolf Bauer’s group at University of Graz as a visiting researcher working on biological screening of Garcinia phytochemicals for nitric oxide and COX inhibitions. He was a postdoctoral fellow in the laboratories of Prof. Warinthorn Chavasiri at CU (2020-2022) and Dr. Sutin Kaennakam at King Mongkut’s University of Technology North Bangkok-KMUTNB (2022-2024) where he worked on natural anticancer and anti-inflammatory agents from edible Garcinia plants collected from Thailand. Back to Indonesia, in September 2024 he was appointed as a lecturer and member of Organic Chemistry Research Group ITB.

At ITB, Dr. Sukandar focuses on the isolation of complex secondary metabolites from medicinal and edible plants, particularly genus Garcinia, using NMR- or bioactivity-guided analysis and determination of their intriguing molecular structures using advanced organic spectroscopy. Working together with other collaborators, his team elucidate the biological effects and molecular mechanisms of such bioactive components against cancer cells and on anti-inflammatory process. Through these research strategies, he and his coworkers aim to obtain lead compounds for further development of anticancer drug candidates.

Figure 1. Our extensive projects on searching bioactive substances from Indonesian Garcinia plants as anticancer agents. There were five completed projects on phytochemical and biological investigations of G. picrorhiza, G. tetrandra, G. cylindrocarpa, G. forbesii, and G. macrantha with notable bioactive metabolites having significant inhibitory activities against human cancer cells, while two Garcinia species in yellow box are currently under way.

Research Grants

1. (2023-2025) Fundamental Fund, KMUTNB
2. (2021-2022) Second Century Fund (C2F) for Postdoctoral Fellowship, CU
3. (2020-2021) Ratchadapisek Somphot Fund for Postdoctoral Fellowship, CU

Publication

1. Sukandar, R.; Mulya, F.; Parasuk, V.; Phuwapraisirisan, P.; Rassameee, K.; Siripong, P.; Kaennakam, S. “Polyprenylated benzoylphloroglucinols isolated from Garcinia species and their cytotoxic effects on cancer cell lines”, ACS Omega 2024,  9, 43689–43696. link
2. Sukandar, R.; Rassamee, K.; Siripong, P.; Kaennakam, S.” Cytotoxic prenylated xanthone derivatives from the twigs of Garcinia cowa”, Natural Product Research, 2024, Available online. link
3. Lertnitikul, N.; Teerasukpimol, L.; Aekanantakul, P.; Pooreecharurot, N.; Sukrong, S.; Boonyong, C.; Poldorn, P.; Rungrotmongkol, T.; Sukandar, E. R.; Aonbangkhen, C.; Suttisri, R. “A new benzoquinone and a new stilbenoid from Paphiopedilum exul (Ridl.) Rolfe”, Natural Product Research 2024, Available online. link
4. Idowu,; Sukandar, E. R.; Nguyen, D. V.; Mulya, F.; Parasuk, V.; Wonganan, P.; Chavasiri, W.; Thiraphibundet, P. “Two new rotenoid glycosides from the rhizomes of Stemona curtisii Hook. f”, Natural Product Research 2024, Available online. link
5. Rifaldi, R.; Sukandar, E. R.; Fadlan, A.; Fatmawati, S.; Purnomo, A. S.; Wairata, J.; Ersam, T. “A new biphenyl from the stem bark of Garcinia macranthaC.Sm”, Natural Product Research 2024, 38, 2697‒2702. link
6. Sukandar, E. R.; Kaennakam, S.; Wongsuwan, S., Chatwichien, J., Krobthong, S., Yingchutrakul, Y., Mahatnirunkul, T., Mulya, F., Parasuk, V.; Harding, D. J.; Tip-pyang, S.; Aonbangkhen, C., Chavasiri, W. “Schomburginones A‒J, geranylated benzophenones from the leaves of Garcinia schomburgkiana and their cytotoxic and anti-inflammatory activities”. Phytochemistry 2023, 211, 113701. link
7. Kaennakam, S.; Sukandar, E. R.; Yahufai, J.; Onsrisawat, P.; Phuwapraisirisan, P.; Tip-pyang, S. “Garcowacinols A-J, Cytotoxic polyprenylated benzoylphloroglucinol derivatives from the twigs of Garcinia cowa”. Phytochemistry 2023, 209, 113622. link
8. Kaennakam, S.; Sukandar, E. R.; Rassamee, K.; Siripong, P.; Tip-pyang, S. “Cytotoxic polyprenylated benzoylphloroglucinol derivatives from the branches of Garcinia schomburgkiana”, Planta Medica 2023, 89, 508-515. link
9. Hengphasatporn, K.; Harada, R.; Wilasluck, P.; Deetanya, P.; Sukandar, E. R.; Chavasiri, W.; Suroengrit, A.; Boonyasuppayakorn, S.; Rungrotmongkol, T.; Wangkanont, K.; Shigeta, Y. “Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMO”. Scientific Report 2022, 12, 17984. link
10. Idris, M.; Sukandar, E. R.; Purnomo, A. S.; Martak, F.; Fatmawati, S. “Antidiabetic, cytotoxic and antioxidant activities of Rhodomyrtus tomentosa leaf extracts”, RSC Advances 2022, 12, 25697-25710. link
11. Sukandar, E. R.; Kaennakam, S.; Raab, P.; Nöst, X.; Rassamee, K.; Bauer, R.; Siripong, P.; Ersam, T.; Tip-pyang, S.; Chavasiri, W. “Cytotoxic and anti-inflammatory activities of dihydroisocoumarin and xanthone derivatives from Garcinia picrorhiza”, Molecules 2021, 26, 6626. link
12. Wairata, J.; Sukandar, E. R.; Fadlan, A.; Purnomo, A. S.; Taher, M.; Ersam, T. “Evaluation of the antioxidant, antidiabetic, and antiplasmodial activities of xanthones isolated from Garcinia forbesii and their in silico studies”, Biomedicines 2021, 9, 1380. link
13. Kaennakam, S.; Sukandar, E. R.; Juntagoot, T.; Siripong, P.; Tip-pyang, S. “Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana”, Journal of Natural Medicines 2021, 75, 871–876. link
14. Kaennakam, S.; Sukandar, E. R.; Hongnak, S.; Rassamee, K.; Siripong, P.; Tip-pyang, S. “Velucarpin D, a new pterocarpan from the stems of Dalbergia velutina and its cytotoxicity”, Natural Product Research 2021, 35, 3925–3930. link
15. Sukandar, E. R.; Kaennakam, S.; Aree, T.; Nöst, X.; Rassamee, K.; Bauer, R.; Siripong, P.; Ersam, T.; Tip-pyang, S. “Picrorhizones A–H, polyprenylated benzoylphloroglucinols from the stem bark of Garcinia picrorhiza”, Journal of Natural Products 2020, 83, 2102–2111. link
16. Sukandar, E. R.; Kaennakam, S.; Rassamee, K.; Ersam, T.; Siripong, P.; Tip-pyang, S. “Tetrandraxanthone A‒I, prenylated and geranylated xanthones from the stem bark of Garcinia tetrandra”, Journal of Natural Products 2019, 82, 1312–1318. link
17. Kaennakam, S.; Sukandar, E. R.; Siripong, P.; Rassamee, K.; Tip-pyang, S. “Cytotoxic chalcones and isoflavones from the stems of Dalbergia velutina”, Phytochemistry letters 2019, 31, 187‒191. link
18. Kaennakam, S.; Sukandar, E. R.; Siripong, P.; Rassamee, K.; Tip-pyang, S. “Veluflavanones A–P, cytotoxic geranylated flavanones from Dalbergia velutina stems”, Journal of Natural Products 2019, 82, 276–282. link
19. Sukandar, E. R.; Kaennakam, S.; Rassamee, K.; Siripong, P.; Fatmawati, S.; Ersam, T.; Tip-pyang, S. “Xanthones and biphenyls from the stems of Garcinia cylindrocarpa and their cytotoxicity”, Fitoterapia 2018, 130, 112–117. link
20. Sukandar, E. R.; Siripong, P.; Khumkratok, S.; Tip-pyang, S. “New depsidones and xanthone from the roots of Garcinia schomburgkiana”, Fitoterapia 2016, 111, 73–77. link
21. Sukandar, E. R.; Ersam, T.; Fatmawati, S.; Siripong, P.; Aree, T.; Tip-pyang, S. “Cylindroxanthones A–C, three new xanthones and their cytotoxicity from the stem bark of Garcinia cylindrocarpa”, Fitoterapia 2016, 108, 62–65. link

National and International Collaboration

1. National Cancer Institute, Thailand
2. Chulalongkorn University, Thailand
3. King Mongkut’s University of Technology North Bangkok, Thailand
4. The University of Tsukuba, Japan
5. Airlangga University, Indonesia
6. National Research and Innovation Agency, Indonesia