Education:

1. March 2011- December 2014
   PhD, Technical Biochemistry, Technische Universität Dortmund, Germany
   Doctoral thesis: Metabolomics, Proteomics, and Transcriptomics of Cannabis sativa L. Trichomes
2. December 2009- February 2011
   PhD student, Pharmaceutical Biology, Groningen University, The Netherlands
3. August 2006- October 2007
   Master, Organic Chemistry, Bandung Institute of Technology, Indonesia
   Master thesis: Secondary metabolites of hairy root cultures of Morus macroura miq 509 with elicitor addition of yeast extract of Saccharomyces cerevisiae
4. August 2002- July 2006
   Bachelor, Chemistry, Bandung Institute of Technology, Indonesia
   Bachelor thesis: Isolasi Metabolit Sekunder dari kultur Akar Rambut Morus macroura Miq 509

Research Interest:

1. Natural product chemistry
2. Application of metabolomics in natural product chemistry
3. Plant tissue cultures for producing bioactive compounds
4. Metabolomics of Indonesian fruits
5. Exploration of bioactive compounds from endophytes
6. Proteomics

Expertise:

1. Natural product Chemistry : Isolation, molecular structure elucidation, plant biotechnology
2. Molecular biology : RNA, DNA, protein, PCR, real time PCR
3. Bioanalytic : metabolomics, proteomics, and transcriptomics/genomics

Research Grants:

1. Evaluasi Profil Metabolit Biji Hijau Kopi Arabika Giling-Basah Dan Giling-Kering Dengan Metabolomik Berbasis 1H NMR [FMIPA.PPMI-1-107-2024]
2. Evaluasi Biosintesis Senyawa adduct Diels-Alder Pada Kultur Akar Morus cathayana Untuk Eksplorasi Antibiotik Baru. Penelitian Kompetitif Nasional ( PPS-PMDSU )-2024
3. Eksplorasi senyawa aktif matoa (Pometia pinnata) untuk kandidat antibiotik dan antidiabetes. Penelitian Kompetitif Nasional ( PFR ) – 2023-2024
4. Eksplorasi Senyawa Bioaktif Dari Jamur Endofit Yang Berasosisasi Dengan Tumbuhan Morus [FMIPA.PPMI-1-78-2023]
5. Evaluasi Profil Metabolit Kopi Arabika Jawa Barat dengan Metabolomik Berbasis NMR dan GCMS. Penelitian Desentralisasi ( PDUPT ) – 2022
6. PPMI KK KIMIA ORGANIK: Eksplorasi Senyawa Aktif Dari Sumber Daya Hayati Indonesia.[FMIPA.PPMI-1-44-2022]
7. Evaluasi Profil Metabolit Kopi Arabika Jawa Barat Dengan Metabolomik Berbasis NMR dan GCMS [LPPM.PN-1-109-2022]
8. Profil Metabolit dan Aktivitas Antidiabetes Kopi Luwak Arabika Sangrai [FMIPA.PN-6-21-2022]
9. Evaluasi Profil Metabolit Kopi Arabika Indonesia Varietas Unggul Dengan Metabolomik Berbasis NMR dan Sifat Antidiabetiknya [FMIPA.PN-6-36-2021]

International Publication:

1. Agustini, D. M., Hermawati, E., Giri-Rachman, E. A., Happyana, N., & Juliawaty, L. D. (2024). Synthesis and Biological Activity Evaluation of Two Derivatives of 7-Aminocephalosporanic Acid. Chemistry Africa, 1-9.
2. Fadilah, A., & Happyana, N. (2024). Metabolite Profiles and Antioxidant Activity of Garut Arabica Green Coffee Beans. Chemistry Africa, 1-10.
3. Happyana, N., Diniresna, A., Pratiwi, A., & Hakim, E. H. (2024). 1H NMR-based metabolic profiling of green beans of Coffea arabica var. sigararutang with different postharvest treatments. Journal of Food Measurement and Characterization, 18(4), 2587-2597.
4. Happyana, N., Hermawati, E., Ellita, S. D., Juliawaty, L. D., Syah, Y. M., & Hakim, E. H. (2024). Procaine treatment altered metabolite profiles of endophytic fungus Talaromyces wortmannii collected from Morus cathayana Hemsl. Phytochemistry Letters, 60, 249-256.
5. Hamdani, A., & Happyana, N. (2024). Metabolite Profiles of Sukabumi Arabica Green Coffee Beans Evaluated by 1H NMR-Based Metabolomics. Molekul, 19(1), 66-75.
6. Fitriani, R., Happyana, N., & Hakim, E. H. (2024). Morushalunin D, a tri-O-bridged Diels-Alder type adduct from Morus alba var. shalun root cultures and the related precursors. Journal of Asian Natural Products Research, 26(6), 756-764.
7. Purnamasari, Y., Hermawati, E., Mujahidin, D., Happyana, N., & Syah, Y. M. (2024). Xanthorrhizol derivatives and their biological properties as caspase-7 inhibitors. Natural Product Research, 1-9.
8. Febrina, L., Happyana, N., & Syah, Y. M. (2023). Metabolic Profiling, Antioxidant Activity, and Alpha-Glucosidase Inhibitory Activity of the Roasted Beans of Luwak (Civet) Coffee. ACS Food Science & Technology, 3(11), 1864-1876.
9. Riga, R., Happyana, N., & Hakim, E. H. (2023). Secondary metabolites from Colletotrichum gloeosporioides isolated from Artocarpus heterophyllus and evaluation of their cytotoxic and antibacterial activities. Natural Product Research, 1-7.
10. Happyana, N., Syah, Y. M., & Hakim, E. H. (2022). Discrimination of Metabolite Profiles of Gayo Roasted Arabica and Robusta Coffees. Molekul, 17(1), 98-106.
11. Febrina, L., Happyana, N., & Syah, Y. M. (2021). Metabolite profiles and antidiabetic activity of the green beans of Luwak (civet) coffees. Food Chemistry, 355, 129496.
12. Riga, R., Happyana, N., Quentmeier, A., Zammarelli, C., Kayser, O., & Hakim, E. H. (2021). Secondary metabolites from Diaporthe lithocarpus isolated from Artocarpus heterophyllus. Natural Product Research, 35(14), 2324-2328.
13. Fitriani, R., Happyana, N., & Hakim, E. H. (2021). Potential cytotoxic Diels-Alder type adducts from liquid medium of Morus alba var. shalun root cultures. Natural Product Research, 35(13), 2274-2278.
14. Happyana, N., Pratiwi, A., & Hakim, E. H. (2021). Metabolite profiles of the green beans of Indonesian Arabica coffee varieties. International Journal of Food Science, 2021(1), 5782578.
15. Happyana, N., Hermawati, E., Syah, Y. M., & Hakim, E. H. (2020). Discrimination of the Indonesian roasted Arabica coffees using 1H NMR-based metabolomics. Current Research in Nutrition and Food Science Journal, 8(2), 479-488.

International Collaborations:

1. Technical University Dortmund, Germany
2. Gifu University, Japan

Contact Me Here:

E-mail: nizar105@itb.ac.id

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