Ade Danova, Ph.D., was born and raised in Majalengka, Indonesia, where he finished his undergraduate study in chemistry at Mulawarman University. He conducted research under the supervision of Professor Dr. Daniel to synthesize polyols based on Moringa oleifera seed oil. He then became highly interested in organic synthesis. In August 2016, he began his M.Sc research under Assistant Professor Dr. rer. nat. Didin Mujahidin in the Department of Chemistry, Institut Teknologi Bandung. His project was to modify Cinchona Alkaloids for organocatalysis. In mid-December 2018, he pursued study Ph.D. under Professor Dr. Warinthorn Chavasiri (His PhD under Professor Sir Derek H.R.Barton, Nobel Prize in Chemistry 1969 from University of Texas A & M, USA) in the Department of Chemistry, Faculty of Science, Chulalongkorn University, Thailand, to synthesize chalcone derivatives, bioactive molecule hybrids, and study anticancer and inhibition mechanisms of several enzymes related to melanin production, type 2 diabetes mellitus, and Alzheimer’s.

Since December 2022, He is a lecturer in the Organic Chemistry Division, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Indonesia. Together with Professor Dr. Yana M. Syah (Alm.) and Dr. Elvira Hermawati, we are working isolation and transformation of small molecules as well as study of inhibition mechanisms of inhibitors with several enzymes related to Melanin Production, Type 2 Diabetes Mellitus, Alzheimer’s, including Tyrosine Kinase (anticancer) and Caspase 3/7 Enzymes.

Research Interest: 

1. Molecular manipulation (synthetic or natural products) uses several organic reaction methods, such as Green Oxidant “halogenation”, multicomponent reactions (MCRs), and hybrid molecules.
2. Study of inhibition mechanism of the inhibitors by targeting several enzymes using spectroscopy and in silico studies.

Figure 1. Research Areas

Research Grants:

1. Anggota Peneliti (2024): Hibah Penelitian “Pengembangan Metode Produksi Bahan Obat (Active Pharmaceutical Ingredient) dari Bahan Baku Terbarukan (BioAPI” didanai oleh program PRIME SteP ADB-ITB.
2. Anggota Peneliti (2024): Penelitian Kompetitif Nasional (PPS-PTM) dengan judul “Sintesis dan Uji Mekanisme Penghambatan Piperidinium Bis-Lawsone sebagai Kandidat Obat Antidiabetes Tipe 2” didanai oleh Kemdikbudristek.
3. Ketua Peneliti (2024): Hibah Joint Research dengan Peneliti Luar Negeri PPMI FMIPA Institut Teknologi Bandung dengan judul “Sintesis dan Uji Inhibisi Sulfonamidacalkon terhadap Enzim EGFR Tirosin Kinase sebagai Kandidat Antikanker Paru-Paru”.
4. Ketua Peneliti (2024): Hibah Penelitian PPMI KK Kimia Organik FMIPA Institut Teknologi Bandung dengan judul “Sintesis dan Uji Inhibisi Senyawa Turunan Timol terhadap Enzim α-Glukosidase sebagai Obat Antidiabetes Tipe II”.
5. Anggota Peneliti (2023-2025): “Pengembangan Sediaan Obat Herbal Terstandar New Prolipid® dengan Teknologi Nano” didanai oleh LPDP RISPRO dan Indofarma.
6. Anggota Peneliti (2022-2023): “Pengembangan Proses Ramah Lingkungan untuk Produksi Parasetamol dan Salbutamol” didanai oleh LPDP RISPRO.

International Publication:

1. Mujahidin, D., Noviany, I., Hermawati, E., Danova, A., Heliawati, L., & Syah, Y.M. (2024). Isolation and Inhibition Study of Eryvarin D and E from the Root Barks of Eryhtrina veriegata against receptor tyrosine kinases. Rasayan Journal of Chemistry, 17(3), 832-837. (Q3)
2. Kurniadewi, F., Aqilah, A. S., Kartika, I. R., Nurjayadi, M., Hermawati, E., & Danova, A. (2024). Garciniaxanthone E and 12b-Hydroxy-des-D-garcigerrin A from The Tree Bark Garcinia dulcis and their Inhibitory Properties against Receptor Tyrosine Kinases. Jurnal Kimia Valensi, 10(1), 20-26. (Q4)
3. Danova, A., Pattanapanyasat, K., Hengphasatporn, K., Shigeta, Y., Rungrotmongkol, T., Hermawati, E., & Chavasiri, W.(2024). Unlocking E-arylidene Steroid Derivatives as Promising α-Glucosidase Inhibitors. Chemistry Select, 9(9), e202303887. (Q2).
4. Nguyen, D. V., Hengphasatporn, K., Danova, A., Suroengrit, A., Boonyasuppayakorn, S., Fujiki, R., Shigeta, Y., Rungrotmongkol, T. & Chavasiri, W. (2023). Structure—yeast α-glucosidase inhibitory activity relationship of 9-O-berberrubine carboxylates. Scientific Reports, 13(1), 18865. (Q1)
5. Poolsri, W., Noitem, R., Jutabha, P., Raveesunthornkiat, M., Danova, A., Chavasiri, W., & Muanprasat, C. (2023). Discovery of a chalcone derivative as an anti-fibrotic agent targeting transforming growth factor-β1 signaling: Potential therapy of renal fibrosis. Biomedicine & Pharmacotherapy, 165, 115098. https://doi.org/10.1016/j.biopha.2023.115098 (Q1)
6. Le, H. T. T., Hioki, Y., Danova, A., Van Nguyen, K., Thuc, H. D., Kita, M., & Chavasiri, W. (2023). α-Glucosidase inhibition of sesquiterpenoids from the heartwood of Mansonia gagei. Phytochemistry, 113778. DOI: https://doi.org/10.1016/j.phytochem.2023.113778 (Q1)
7. Danova, A., Nguyen, D. V., Toyoda, R., Mahalapbutr, P., Rungrotmongkol, T., Wonganan, P., & Chavasiri, W. (2022). 3′, 4′, 5′-Trimethoxy-and 3, 4-Dimethoxychalcones Targeting A549 Cells: Synthesis, Cytotoxic Activity, and Molecular Docking. Journal of Molecular Structure, 134572. DOI: https://doi.org/10.1016/j.molstruc.2022.134572 (Q2)
8. Le, H. T. T., Nguyen, L. H., Nguyen, T. H., Nguyen, V. K., Danova, A., Truong, T. N., & Chavasiri, W. (2022). Gagone A–F: Six prenylated chalcones from the heartwood of Mansonia gagei. Phytochemistry, 113516. DOI: https://doi.org/10.1016/j.phytochem.2022.113516 (Q1)
9. Le, T.K.D., Danova, A., Aree, T., Duong, T.H., Koketsu, M., Ninomiya, M., Sawada, Y., Kamsri, P., Pungpo, P. & Chavasiri, W. (2022). α-Glucosidase Inhibitors from the Stems of Knema globularia. Journal of Natural Products. DOI: https://doi.org/10.1021/acs.jnatprod.1c00765 (Q1)

Patent:

1. Proses Pembuatan Obat Jantung Bisoprolol Melalui Prekursor 4-((2-
   Isopropoksietoksi)Metil)Fenol. No. P00202312605 (Pemeriksaan Formalitas oleh DJKI 2023).
2. Proses Pembuatan 6-(1-Tersier Butilamin Etan-1-Ol)-1,3-Benzodioksan Sebagai Prekursor Obat Salbutamol. No. S00202309898 (Terdaftar oleh DJKI 2023).
3. Metode Pemurnian Senyawa 6-Fluoro-3-Hidroksipirazin-2-Karboksamida Sebagai Obat Antivirus Rna. No. P00202307068 (Pemeriksaan Formalitas oleh DJKI 2023).

International Collaboration:

1. Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330 Thailand.
2. Chulabhorn Graduate Institute, Thailand.
3. Laboratory of Biophysics, Institute for Advance Study in Technology, Ton Duc Thang University, Thailand.
4. Center for Computational Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577 Japan.
5. Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Non-Degree Training:

1. Basic 1D and 2D NMR – Introduction to AVANCE spectrometer operation certified by BRUKER, 2-6 September 2024, Fallanden, Switzerland.
2. Pelatihan PEKERTI (Peningkatan Keterampilan Dasar Teknik Instruksional), Universitas Pendidikan Indonesia, 2023.
3. Pembinaan dan Pelaksanaan Pemantapan Nilai-Nilai Kebangsaan Secara Virtual Angkatan II, Lembaga Ketahanan Nasional Republik Indonesia (The National Resilience Institute, Indonesia), 2022.

Touch Me Here:

E-mail: adedanova@itb.ac.id

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